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A&M 111

6,990.00 5,199.00

Auris Medical is developing A&M-111 for the treatment of acute inner ear (sensorineural) hearing loss (ASNHL). AM-111 contains brimapitide, or D-JNKI-1 (D-stereoisomer of c-Jun N-Terminal Kinase Inhibitor 1), an inhibitor of the JNK stress kinase coupled to an intracellular transporter. AM-111 is formulated in a biocompatible and fully biodegradable gel and administered in a single dose intratympanic injection into the middle ear. From there the drug diffuses through the round window membrane into the cochlea.

Description

  • Auris Medical is conducting two pivotal clinical trials with AM-111 in the treatment of ISSNHL: the HEALOS trial ((Efficacy and Safety of AM-111 in the Treatment of Acute Inner Ear Hearing Loss) Europe/Asia, initiated in Q4/2015) and the ASSENT trial (Efficacy and Safety of AM-111 as Acute Sudden Sensorineural Hearing Loss Treatment; North
  • AM-111 was safe and well tolerated in the Phase 2 clinical trial. There were no statistically significant differences in the occurrence of clinically relevant hearing deterioration in the treated ear

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